You can use the importprivkey command to add a private key to the node's wallet, and you can add multisig addresses using importaddress. But I'm not sure what you mean why you ask "can the node address be a multisig address" because there is no such thing as a single node address. But if you mean the address that a node uses for handshaking with other nodes in the peer-to-peer protocol, this cannot be a multisig address.